AR antagonist 1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AR 拮抗剂 1 是雄激素受体的有效拮抗剂。在 PROTAC ARD-266 的合成中，它与 E3 连接酶配体结合，对 VHL 蛋白具有弱结合亲和力。

AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.(In Vitro):AR antagonist 1 (compound 29) is the ligand for the target ligase of ARD-266. ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex, it can be successfully employed for the design of highly potent and efficient PROTAC degraders.

AR antagonist 1 (compound 29) is the ligand for target ligase ofARD-266. ARD-266 is a highly potent and VHL E3 ligase-based?androgen receptor (AR)?PROTAC degrader. AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex, it can be successfully employed for the design of highly potent and efficient PROTAC degraders. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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Endocrinology/Hormones

Androgen Receptor (AR)

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1818885-54-9

278.78

C15H19ClN2O

>98% (HPLC)

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N#CC1=CC=C(O[C@H]2C(C)(C)[C@H](N)C2(C)C)C=C1Cl

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(-20℃)

With Ice Pack

≥ 2 years