48740 RP

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

48740 RP 是血小板激活因子的拮抗剂。

48740 RP is an antagonist of platelet-activating factor.(In Vivo):48740 RP significantly reduces capillary permeability. 48740 RP increases the number of platelets at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. 48740 RP in combination with the LPS exposure increases the number of neutrophils by about half at 24 h.

——

48740 RP (RP-55778) is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability.

RP-55778 | RP-48740 | RP 55779 | RP 55778

Others

Platelet aggregation

Bacterial| P-gp?(P-glycoprotein)

——

——

93363-11-2

245.3

C12H11N3OS

>98% (HPLC)

——

NC(=O)c1ccn2C(SCc12)c1cccnc1

——

(-20℃)

With Ice Pack

≥ 2 years