CCI 007

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CCI 007 是 MLL-r、CALM-AF10 和 SET-NUP214 白血病的选择性抑制剂，针对 MLL-r 白血病细胞系 PER-485 的 IC50 为 3.5 uM。

CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485

CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia.Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2.Resistance to CCI-007 can occur by upregulation of MLL target gene expression. :Cell Viability Assay Cell Line:PER-485, MOLM-13, MV4;11 cells.Concentration:5 μM.Incubation Time:24 h.Result:Induced apoptosis.

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Chromatin/Epigenetic

Histone Demethylase

MLL-r

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939228-52-1

336.36

C15H16N2O5S

>98% (HPLC)

DMSO:10 mM

O=C(OCC)COC(C=CC(C=C1SC(N)=NC1=O)=C2)=C2OC

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(-20℃)

With Ice Pack

≥ 2 years