021-51111890
购物车（）
sales@molnova.cn
Rotigotine (b)
CAS No. 92206-54-7
Rotigotine (b) ( 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- )
产品货号. M24970 CAS No. 92206-54-7
罗替高汀是一种抗帕金森病药和多巴胺受体激动剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥186 | 有现货 |
|
| 10MG | ￥300 | 有现货 |
|
| 25MG | ￥489 | 有现货 |
|
| 50MG | ￥720 | 有现货 |
|
| 100MG | ￥1035 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥220 | 有现货 |
|
生物学信息
-
产品名称Rotigotine (b)
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述罗替高汀是一种抗帕金森病药和多巴胺受体激动剂。
-
产品描述Rotigotine is an antiparkinson agent and dopamine receptor agonist.
-
体外实验Rotigotine has a 10-fold selectivity for D3 (pKi=9.2) receptors compared with D2, D4 and D5 (pKi=8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi=7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7).Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.
-
体内实验——
-
同义词1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-
-
通路GPCR/G Protein
-
靶点Dopamine Receptor
-
受体Dopamine
-
研究领域——
-
适应症——
化学信息
-
CAS Number92206-54-7
-
分子量315.47
-
分子式C19H25NOS
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCCCN(CCc1cccs1)C(CC1)Cc2c1c(O)ccc2
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Chen F , Jin L , Nie Z . Safety and Efficacy of Rotigotine for Treating Parkinson's Disease: A Meta-Analysis of Randomised Controlled Trials[J]. Journal of Pharmacy & Pharmaceutical Sciences, 2017, 20:285-.
产品手册
关联产品
-
Apomorphine hydrochl...
阿扑吗啡盐酸盐半水合物是一种非选择性多巴胺激动剂，可激活 D1 样和 D2 样受体。
-
UNC9975
UNC9975 is a beta-inhibitory protein-biased dopamine D(2) receptor agonist with antipsychotic activity and can be used to study neurologic disorders such as schizophrenia.
-
Medifoxamine
Medifoxamine 是一种抑制单胺再摄取的抗抑郁活性分子，优先抑制多巴胺再摄取 (dopamine reuptake)。
