Shield-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Shield-1 是 FK506 结合蛋白 12 (FKBP) 的特异性、高亲和力和细胞渗透性配体，通过与突变的 FKBP (mtFKBP) 结合来逆转不稳定性，从而允许 mtFKBP 融合蛋白的条件表达。 Shield-1可以稳定整个融合蛋白。

Shield-1 is a specific, high-affinity and cell-permeant ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize the entire fusion protein.

Western Blot Analysis Cell Line:NIH3T3 cellsConcentration:0.1 nM-1 μM Incubation Time:Result:Stabilized the YFP fusion protein of L106P by higher concentrations of Shld1 (EC50～100 nM).Western Blot Analysis Cell Line:HEK293 cells Concentration:1 μM Incubation Time:24 hours Result:Expressed both TRPV5 and YFP well when Shield-1 in the medium, whereas in the abscence of Shield-1 decreased TRPV5 or YFP protein expression.

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Others

Other Targets

FKBP

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914805-33-7

748.9

C42H56N2O10

>98% (HPLC)

DMSO:250 mg/mL (333.82 mM)

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC(OCCN4CCOCC4)=C3)CCC5=CC=C(OC)C(OC)=C5

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(-20℃)

With Ice Pack

≥ 2 years