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PIK-108
CAS No. 901398-68-3
PIK-108 ( PIK 108 | PIK108 )
产品货号. M24934 CAS No. 901398-68-3
PIK-108 是磷脂酰肌醇-4,5-二磷酸 3-激酶催化亚基 β 和 δ (PI3Kβ/δ) 的变构抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥895 | 有现货 |
|
| 10MG | ￥1349 | 有现货 |
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| 25MG | ￥2213 | 有现货 |
|
| 50MG | ￥3218 | 有现货 |
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| 100MG | ￥4194 | 有现货 |
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| 200MG | ￥5661 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥743 | 有现货 |
|
生物学信息
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产品名称PIK-108
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PIK-108 是磷脂酰肌醇-4,5-二磷酸 3-激酶催化亚基 β 和 δ (PI3Kβ/δ) 的变构抑制剂。
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产品描述PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
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体外实验PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt.Western Blot Analysis Cell Line:Glioma cell lines expressing wild-type PTEN Concentration:0.1, 0.5, 1, 4, and 10 μM Incubation Time:1 hour Result:Showed variable inhibition of PKB/Akt phosphorylation but exhibited a trend toward reducing PKB/Akt phosphorylation more effectively in mutant PTEN-expressing cell lines than in wild-type PTEN-expressing cell lines.
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体内实验——
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同义词PIK 108 | PIK108
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通路PI3K/Akt/mTOR signaling
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靶点PI3K
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受体PI3Kα|PI3Kβ
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研究领域——
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适应症——
化学信息
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CAS Number901398-68-3
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分子量364.44
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分子式C22H24N2O3
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纯度>98% (HPLC)
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溶解度DMSO:45 mg/mL?(123.48 mM;?Need ultrasonic)
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SMILESO=C1C=C(N2CCOCC2)OC3=C(C(NC4=CC=CC=C4)C)C=C(C)C=C13
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Certal V, Halley F, Virone-Oddos A, Delorme C, Karlsson A, Rak A, Thompson F, Filoche-Rommé B, El-Ahmad Y, Carry JC et al.. (2012) Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. J. Med. Chem., 55 (10): 4788-805. [PMID:22524426]
产品手册
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