trans-AUCB

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

trans-AUCB 是一种有效的选择性可溶性环氧化物水解酶抑制剂。

trans-AUCB is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively).

Cell Viability Assay Cell Line:U251, U87 cells Concentration:25, 50, 100, 200, or 300 μM Incubation Time:48 hours Result:Suppressed U251 and U87 cell growth in a dose-dependent manner.Cell Cycle Analysis Cell Line:U251, U87 cells Concentration:200 μM Incubation Time:48 or 96 hours Result:Induced cell-cycle G0/G1 phase arrest in U251 and U87 cells. Western Blot Analysis Cell Line:U251, U87 cells Concentration:200 μM Incubation Time:10 min, 30 min, 1 hour, 2 hours, or 4 hours Result:Increased the phosphorylation levels of p65 after 10 min, reached to peak after 30 min and lasted for at least 2 hours.

Animal Model:Mice (male CFW strain, 7 weeks old, 24-30 g; and male C57BL/6 strain, 8 weeks old, 22-25 g) Dosage:0.1, 0.5, 1 mg/kg Administration:PO Result:Ameliorated the LPS-induced hypotension in a dose-dependent manner.Animal Model:Mice (male CFW strain, 7 weeks old, 24-30 g; and male C57BL/6 strain, 8 weeks old, 22-25 g) Dosage:0.1, 0.5, 1 mg/kg (Pharmacokinetic Analysis)Administration:PO Result:Had t1/2 values of 20, 30, 15 min and Cmax values of 30, 100, 150 nmol/L for p.o. of 0.1, 0.5, 1 mg/kg, respectively.

t-AUCB

Others

Other Targets

sEH

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885012-33-9

412.52

C24H32N2O4

>98% (HPLC)

DMSO:100 mg/mL (242.41 mM; Need ultrasonic)

O=C(O)C1=CC=C(O[C@H]2CC[C@H](NC(NC34CC5CC(C4)CC(C5)C3)=O)CC2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years