GW604714X?

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GW604714X被发现是由丙酮酸支持的线粒体呼吸的有效抑制剂。

GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.

GW604714X inhibits the mitochondrial pyruvate carrier (MPC) with?Ki?value <0.1 μM in direct measurement of pyruvate transport into rat liver and yeast?mitochondria.Inhibitor?titrations?of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites and their?Ki?(nM) of 56.0 nM and 0.057 nM for the GW604714X.GW604714X inhibits the transport of 0.5 mM [14C]-l-lactate into rat red blood cells, mediated by the monocarboxylate transporter MCT1. GW604714X at 10 μM reduces the initial rate of uptake to 30% of control values.

——

2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

Others

Other Targets

Mitochondrial Metabolism

——

——

853953-65-8

471.46

C21H18FN5O5S

>98% (HPLC)

DMF:5mg/ml(10.61mM; need ultrasonic)

O=C(NC1=O)SC1=CC2=CC(C3=NC(N4CCN(C(C)=O)CC4)=CC=C3[N+]([O-])=O)=CC=C2F

——

(-20℃)

With Ice Pack

≥ 2 years