021-51111890
购物车（）
sales@molnova.cn
SHA 68
CAS No. 847553-89-3
SHA 68 ( —— )
产品货号. M24842 CAS No. 847553-89-3
SHA 68 是神经肽 S 受体 (NPSR) 的有效选择性非肽拮抗剂（NPSR Asn107 和 NPSR Ile107，IC50 分别为 22.0 和 23.8 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥582 | 有现货 |
|
| 5MG | ￥829 | 有现货 |
|
| 10MG | ￥1191 | 有现货 |
|
| 25MG | ￥2717 | 有现货 |
|
| 50MG | ￥4542 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称SHA 68
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述SHA 68 是神经肽 S 受体 (NPSR) 的有效选择性非肽拮抗剂（NPSR Asn107 和 NPSR Ile107，IC50 分别为 22.0 和 23.8 nM）。
-
产品描述SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
-
体外实验——
-
体内实验Animal Model:Male C57BL/6 mice age 8-12 weeksDosage:5 and 50 mg/kg Administration:i.p.Result:Reduced NPS-induced horizontal activity and vertical rearing and climbing.Animal Model:Male C57BL/6 mice age 8-12 weeks Dosage:1 mg/kg (Pharmacokinetic Analysis) Administration:i.p.Result:Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.
-
同义词——
-
通路GPCR/G Protein
-
靶点Neuropeptide Y Receptor
-
受体NPSR Asn107|NPSR Ile107
-
研究领域——
-
适应症——
化学信息
-
CAS Number847553-89-3
-
分子量445.49
-
分子式C26H24FN3O3
-
纯度>98% (HPLC)
-
溶解度DMSO:250 mg/mL (561.18 mM; Need ultrasonic)
-
SMILESO=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCC5=CC=C(F)C=C5
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Okamura N, et al. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun;325(3):893-901.
产品手册
关联产品
-
M 1145
Potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin.
-
Peptide YY (PYY), hu...
Peptide YY (PYY), a novel 36 amino-acid amidated hormone is a component of the complex neuroendocrine control process.Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.
-
RFRP 3 (human)
Agonist of the NPFF1 receptor (IC50 = 0.7 nM for inhibition of forskolin-induced cAMP production). Homolog of gonadotropin-inhibitory hormone (GnIH); inhibits activity of gonadotropin-releasing hormone (GnRH) neurons.
