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SHA 68
CAS No. 847553-89-3
SHA 68 ( —— )
产品货号. M24842 CAS No. 847553-89-3
SHA 68 是神经肽 S 受体 (NPSR) 的有效选择性非肽拮抗剂（NPSR Asn107 和 NPSR Ile107，IC50 分别为 22.0 和 23.8 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥582 | 有现货 |
|
| 5MG | ￥829 | 有现货 |
|
| 10MG | ￥1191 | 有现货 |
|
| 25MG | ￥2717 | 有现货 |
|
| 50MG | ￥4542 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SHA 68
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SHA 68 是神经肽 S 受体 (NPSR) 的有效选择性非肽拮抗剂（NPSR Asn107 和 NPSR Ile107，IC50 分别为 22.0 和 23.8 nM）。
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产品描述SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
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体外实验——
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体内实验Animal Model:Male C57BL/6 mice age 8-12 weeksDosage:5 and 50 mg/kg Administration:i.p.Result:Reduced NPS-induced horizontal activity and vertical rearing and climbing.Animal Model:Male C57BL/6 mice age 8-12 weeks Dosage:1 mg/kg (Pharmacokinetic Analysis) Administration:i.p.Result:Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.
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同义词——
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通路GPCR/G Protein
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靶点Neuropeptide Y Receptor
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受体NPSR Asn107|NPSR Ile107
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研究领域——
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适应症——
化学信息
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CAS Number847553-89-3
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分子量445.49
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分子式C26H24FN3O3
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纯度>98% (HPLC)
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溶解度DMSO:250 mg/mL (561.18 mM; Need ultrasonic)
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SMILESO=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCC5=CC=C(F)C=C5
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Okamura N, et al. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun;325(3):893-901.
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