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DM4
CAS No. 796073-69-3
DM4 ( Ravtansine )
产品货号. M24795 CAS No. 796073-69-3
DM4可用于制备抗体药物缀合物，是一种抗微管蛋白剂。它可以抑制细胞分裂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥550 | 有现货 |
|
| 10MG | ￥842 | 有现货 |
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| 25MG | ￥1479 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥720 | 有现货 |
|
生物学信息
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产品名称DM4
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DM4可用于制备抗体药物缀合物，是一种抗微管蛋白剂。它可以抑制细胞分裂。
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产品描述DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
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体外实验DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death.
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体内实验——
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同义词Ravtansine
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number796073-69-3
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分子量780.37
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分子式C38H54ClN3O10S
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纯度>98% (HPLC)
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溶解度DMSO: 99 mg/mL (126.86 mM; Need ultrasonic)
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SMILESCO[C@@H]1/C=C/C=C(Cc2cc(N(C(C[C@@H]([C@@]3(O[C@H]3[C@@H]([C@@H]4C[C@]1(NC(O4)=O)O)C)C)OC([C@@H](N(C(CCC(C)(S)C)=O)C)C)=O)=O)C)c(Cl)c(OC)c2)\C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
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