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Indirubin-3-monoxime
CAS No. 667463-82-3
Indirubin-3-monoxime ( —— )
产品货号. M24681 CAS No. 667463-82-3
Indirubin-3-monoxime 是细胞周期蛋白依赖性蛋白激酶的有效抑制剂，可能在阿尔茨海默病的神经元凋亡中发挥重要作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥822 | 有现货 |
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| 10MG | ￥1254 | 有现货 |
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| 25MG | ￥2446 | 有现货 |
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| 50MG | ￥3655 | 有现货 |
|
| 100MG | ￥5067 | 有现货 |
|
| 200MG | ￥6867 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥778 | 有现货 |
|
生物学信息
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产品名称Indirubin-3-monoxime
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Indirubin-3-monoxime 是细胞周期蛋白依赖性蛋白激酶的有效抑制剂，可能在阿尔茨海默病的神经元凋亡中发挥重要作用。
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产品描述Indirubin-3-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
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体外实验In cerebellar granule neurons (CGNs), Indirubin-3′-oxime blocks c-Jun phosphorylation induced by potassium withdrawal and prevented CGNs from apoptosis in a dose dependent manner. Indirubin-3′-oxime (IDR3O) (PC12 cells; 10 μM) significantly prevent 6OHDA-induced decrease of nuclear localized MEF2D expression.
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体内实验Indirubin-3′-oxime (0.05 or 0.5?mg/kg; i.p.; daily for 2 or 10 weeks) enhances tibial longitudinal growth in mice without adverse changes in bone thickness parameters. Animal Model:Three-week-old C57BL/6 mice Dosage:0.05 or 0.5?mg/kg Administration:I.p.; daily for 2 or 10 weeks Result:The tibial length of mice increased in a dose-dependent manner.
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同义词——
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通路Angiogenesis
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靶点CDK
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受体cdk
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研究领域——
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适应症——
化学信息
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CAS Number667463-82-3
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分子量277.28
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分子式C16H11N3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (360.65 mM)
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SMILESOc([nH]c1c2cccc1)c2-c([nH]c1c2cccc1)c2N=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Dera A A , Rajagopalan P , Fayi M A , et al. Indirubin-3-monoxime and thymoquinone exhibit synergistic efficacy as therapeutic combination in in-vitro and in-vivo models of Lung cancer[J]. Archives of Pharmacal Research, 2020, 43(10).
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