AH 7614

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AH 7614 是一种选择性且有效的游离脂肪酸受体 4 (FFA4/GPR120) 拮抗剂。

AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.

AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells.?AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells.AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50=7.70).AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.

AH7614 (50μg; intratumoral injection once every 4?d for 20 d) reduces the tumor growth in mice.AH7614 (50μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.

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Cell Cycle/DNA Damage

GPR

GPR120

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6326-06-3

351.42

C20H17NO3S

>98% (HPLC)

DMSO:35.1 mg/mL(100 mM);Ethanol:Insoluble;Water:Insoluble

O=S(C1=CC=C(C)C=C1)(NC2C3=C(OC4=C2C=CC=C4)C=CC=C3)=O

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(-20℃)

With Ice Pack

≥ 2 years