Sinefungin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sinefungin 是病毒体 mRNA(鸟嘌呤-7-)-甲基转移酶、mRNA(核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。

Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.

Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells. Western Blot Analysis Cell Line:Renal epithelial cells.Concentration:0.5 or 1.0 μg/mL.Incubation Time:Pretreatment 60 minutes before TGF-β1 (10 ng/mL).Result:Significantly reduced TGF-β1-inducedα-SMA protein expression and inhibited H3K4me1 in a dose-dependent manner in both NRK-52E and NRK-49F cells.

Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy. Animal Model:Male C57BL/6J mice (8 weeks of age).Dosage:10 mg/kg Administration:Administered intraperitoneally per day immediately after UUO (prepared as a suspension in distilled water and 0.9% NaCl solution).Result:Inhibited α-SMA protein expression.Ameliorated those (α-SMA, FSP-1, collagen 1, collagen 3) both at 3 and 7 days after UUO.

Adenosyl-Ornithine | A-9145 | Antibiotic 32232RP

Others

Other Targets

SET7/9

——

——

58944-73-3

381.39

C15H23N7O5

>98% (HPLC)

H2O:95 mg/mL (249.09 mM; Need ultrasonic)

N[C@H](CC[C@H](C(O)=O)N)C[C@@H]([C@@H]([C@@H]1O)O)O[C@@H]1n1c2ncnc(N)c2nc1

——

(-20℃)

With Ice Pack

≥ 2 years