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Cystamine dihydrochloride
CAS No. 56-17-7
Cystamine dihydrochloride ( —— )
产品货号. M24550 CAS No. 56-17-7
Cystamine diHClide 是一种辐射防护剂。它还可以防止四氯化碳肝损伤。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥185 | 有现货 |
|
生物学信息
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产品名称Cystamine dihydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Cystamine diHClide 是一种辐射防护剂。它还可以防止四氯化碳肝损伤。
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产品描述Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.
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体外实验Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50 value of 23.6 μM.Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione. Western Blot Analysis Cell Line:Human neuroblastoma SH-SY5Y cells Concentration:250, 500 μM Incubation Time:0-16 h Result:Inhibited the MG132-mediated activation of caspase-3.Inhibited the H2O2-mediated activation of caspase-3.Inhibited caspase-3 activity in a tTG-independent manner.
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体内实验Cystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice. Animal Model:R6/2 transgenic HD miceDosage:112, 225 mg/kg Administration:Intraperitoneal or oral, daily Result:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number56-17-7
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分子量225.19
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分子式C4H14Cl2N2S2
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纯度>98% (HPLC)
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溶解度DMSO:Soluble
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SMILESC(CSSCCN)N.Cl.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Roncoroni L, Elli L, Braidotti P, et al. Transglutaminase 2 Mediates the Cytotoxicity of Resveratrol in a Human Cholangiocarcinoma and Gallbladder Cancer Cell Lines. Nutr Cancer. 2018 May 14:1-9.
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