BPH-1358

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BPH-1358 (NSC50460) 是一种有效的人法尼基二磷酸合成酶 (FPPS) 和十一碳烯基二磷酸合成酶 (UPPS) 抑制剂。

BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL).

BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively.

BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain).

NSC50460

Others

Other Targets

human bisphosphonate farnesyl diphosphate synthase

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5352-53-4

601.53

C32H30Cl2N6O2

>98% (HPLC)

In Vitro:?DMSO : 6.25 mg/mL (10.39 mM)

O=C(C1=CC=C(C2=CC=C(C(NC3=CC=CC(C4=NCCN4)=C3)=O)C=C2)C=C1)NC5=CC=CC(C6=NCCN6)=C5.[H]Cl.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years