5-Hydroxymethyldeoxyuridine ( —— )

产品货号. M24477 CAS No. 5116-24-5

COA

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HNMR

HPLC

MSDS

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产品名称

5-Hydroxymethyldeoxyuridine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

5-羟甲基脱氧尿苷是一种核苷类似物，具有抗癌和抗病毒活性。
产品描述

5-Hydroxymethyldeoxyuridine is an analog of nucleoside that has anticancer and antiviral activities. It suppresses the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8.5 and 4 μM, respectively) and multiple human leukemia cell lines (IC50s = 1.7-5.8 μM).
体外实验

5-Hydroxymethyl-2'-deoxyuridine (0-10 μM) inhibits the replication of Sarcoma 180 cells and Ehrlich ascites carcinoma cells with ED50 values of 8.5 and 4 μM, respectively. 5-Hydroxymethyl-2'-deoxyuridine inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase with a Ki value of 3.5 μM.5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM.5-Hydroxymethyl-2'-deoxyuridine (10-100 μM) shows dose-dependent toxicity against a human acute promyelocytic leukemia cell line.
体内实验

5-Hydroxymethyl-2'-deoxyuridine (0, 5 and 50 mg/kg; i.p.; once) increases the survival of DBA/2 mice carrying L1210 leukemia.
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