WR99210

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

WR99210 可有效对抗大多数对乙胺嘧啶耐药的恶性疟原虫菌株。

WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. WR99210 is an effective inhibitor of dihydrofolate reductase (IC50:<0.075 nM).

WR99210 (0-100 nM; 92 h) is highly effective against T. gondii tachyzoites in tissue culture.WR99210 (0-100 nM; 92 h) shows low cytotoxicity to human foreskin fibroblasts.Cell Viability Assay Cell Line:Human foreskin fibroblasts (T. gondii-infected)Concentration:0-100 nM Incubation Time:92 h Result:Showed marked inhibition of T. gondii, with an IC50 value of approximately 50 nM.Cell Cytotoxicity Assay Cell Line:Human foreskin fibroblasts Concentration:0-100 nM Incubation Time:92 h Result:Lacked of toxicity for fibroblasts.

WR99210 (1.25 mg/kg; i.p.; single daily for 5 days) is highly effective against T. gondii tachyzoites in a mouse model. Animal Model:Male mice (T. gondii-infected).Dosage:1.25 mg/kg Administration:Intraperitoneal injection; single daily for 5 days.Result:Exhibited intraperitoneal parasite numbers were 2 logs less in mice on the day 5.

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Cell Cycle/DNA Damage

DHFR

DHFR

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47326-86-3

394.68

C14H18Cl3N5O2

>98% (HPLC)

DMSO : 5 mg/mL (12.67 mM; Need ultrasonic)

CC1(N=C(N=C(N1OCCCOC2=C(C=C(C(Cl)=C2)Cl)Cl)N)N)C

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(-20℃)

With Ice Pack

≥ 2 years