Toddaculin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Toddaculine可能有益于预防和治疗骨质疏松症，它不仅可以通过激活NF-κB、ERK 1/2和p38 MAPK信号通路来抑制破骨细胞的分化。

Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.

Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM.Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells.

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Others

Other Targets

Others

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4335-12-0

274.3

C16H18O4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (182.28 mM)

CC(C)=CCc(c(OC)cc(O1)c2C=CC1=O)c2OC

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(-20℃)

With Ice Pack

≥ 2 years