Emodin 6-O-β-D-glucoside

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

大黄素 6-O-β-D-葡萄糖苷可以保护屏障完整性并抑制 HMGB1 介导的炎症反应，这表明其有可能用于治疗脓毒症或脓毒性休克。

Emodin 6-O-β-D-glucoside can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis.

Emodin-6-O-β-D-glucoside (0~20 μM; 24 hours; HUVECs) does not affect cell viability.Emodin-6-O-β-D-glucoside (0~10 μM; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin and results in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA.Emodin-6-O-β-D-glucoside (10 μM; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs.Emodin-6-O-β-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation and p65 NF-κB expression levels increase. Cell Viability Assay Cell Line:HUVECs Concentration:0~20 μM Incubation Time:24 hours Result:Did not affect cell viability.Western Blot Analysis Cell Line:HUVECs Concentration:0~10 μM Incubation Time:6 hours Result:Inhibited high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin.RT-PCRCell Line:HUVECs Concentration:0~10 μM Incubation Time:6 hours Result:Resulted in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA.Immunofluorescence Cell Line:HUVECsConcentration:10 μM Incubation Time:6 hours Result:Resulted in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs.

Emodin-6-O-β-D-glucoside (0~9 mg/mouse; i.v.) markly inhibits peritoneal leakage of dye induced by high glucose. Animal Model:Mouse Dosage:0~9 mg/mouse Administration:I.v.Result:Markly inhibited peritoneal leakage of dye induced by high glucose.

Glucoemodin

Others

Other Targets

Others

——

——

34298-85-6

432.38

C21H20O10

>98% (HPLC)

——

Cc(cc1C(c2cc(O[C@@H]([C@@H]([C@H]3O)O)O[C@H](CO)[C@H]3O)cc(O)c22)=O)cc(O)c1C2=O

——

(-20℃)

With Ice Pack

≥ 2 years