FAUC-213

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FAUC-213 是多巴胺 D4 受体的选择性完全拮抗剂。

FAUC-213 is a selective full antagonist of the dopamine D4 receptor.

FAUC 213 inhibits p5-HT1 (Ki=1.2 μM)，p5-HT2 (Ki=0.52 μM)，pα1 (Ki=0.27 μM).

FAUC 213 (7.5-30 mg/kg; orally; single dose) significantly reduces this elevation in AMPH-induced locomotor hyper-activity only pre-treatment with 30 mg/kg. FAUC 213 significantly restores the prepulse inhibition (PPI) reduction caused by the apomorphine (APO) treatment with 30 mg/kg. Animal Model:Male adult Wistar rats weighing 300-350 g Dosage:7.5, 15, 30 mg/kg Administration:Orally; single dose Result:Significantly reduced this elevation in amphetamin (AMPH)-induced locomotor hyper-activity only pre-treatment with 30 mg/kg.

FAUC 213 | FAUC213

GPCR/G Protein

Dopamine Receptor

D4

——

——

337972-47-1

326.82

C18H19ClN4

>98% (HPLC)

DMSO:10 mM

C1CN(CCN1CC2=NN3C=CC=CC3=C2)C4=CC=C(C=C4)Cl

——

(-20℃)

With Ice Pack

≥ 2 years