D-Leucine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

即使在癫痫发作后，D-亮氨酸也能有效终止癫痫发作。

D-Leucine potently terminates seizures even after the onset of seizure activity. D-leucine reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.

In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes.

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(R)-Leucine

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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328-38-1

131.17

C6H13NO2

>98% (HPLC)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

CC(C)C[C@H](C(O)=O)N

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(-20℃)

With Ice Pack

≥ 2 years