Deoxyelephantopin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Deoxyelephantopin 具有抗炎、保肝和伤口愈合活性；它还具有抗肿瘤活性。Deoxyelephantopin 抑制 NF-κB、MAPK、PI3K/Akt 和 β-catenin 信号传导。

Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities;?it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling.

Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively.Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells.

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Apoptosis

NF-κB

NF-κB

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29307-03-7

344.37

C19H20O6

>98% (HPLC)

DMSO:10 mM

O=C(O[C@H]([C@]([H])([C@]([H])(OC1=O)C=C(C)C2)C1=C)CC3=C[C@@]2(OC3=O)[H])C(C)=C

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(-20℃)

With Ice Pack

≥ 2 years