CID 2745687 ( —— )

产品货号. M24173 CAS No. 264233-05-8

CID 2745687 是一种 GPR35 拮抗剂，可抑制色甘酸二钠和扎普司特（两种共享重叠结合位点的激动剂）对 GPR35 的作用。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥616	有现货
5MG	￥1026	有现货
10MG	￥1644	有现货
25MG	￥3264	有现货
50MG	￥4622	有现货
100MG	￥6471	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥1121	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

CID 2745687
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CID 2745687 是一种 GPR35 拮抗剂，可抑制色甘酸二钠和扎普司特（两种共享重叠结合位点的激动剂）对 GPR35 的作用。
产品描述

CID 2745687 is a GPR35 antagonist that inhibited the effects at human GPR35 of cromolyn disodium and zaprinast, two agonists that share an overlapping binding site.
体外实验

For ERK1/2 phosphorylation with 1 μM Pamoic acid as the agonist, the CID 2745687 (CID2745687) Ki is 18 nM. CID 2745687 (CID-2745687) is a potent antagonist in β-arrestin-2 interaction assays only at human GPR35.Using the BRET-based GPR35-β-arrestin-2 interaction assay and an EC80 concentration of Zaprinast (20 μM) as agonist, CID 2745687 behaved as a moderately potent, concentration-dependent antagonist at human GPR35 with pIC50=6.70±0.09.CID 2745687 (pIC50=6.27±0.08) fully reverses the agonist action of Cromolyn disodium .
体内实验

CID 2745687 (CID2745687; 1 mg/kg; administrated orally every day for the last 4 weeks), a specific GPR35 antagonist, reverses Lodoxamide-mediated anti-fibrotic effects. Animal Model:Six-week-old male C57BL/6 miceDosage:1 mg/kgAdministration:Oral administration, every day for 4 weeks Result:Inhibited Lodoxamide-mediated protective effects.
同义词

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通路

Cell Cycle/DNA Damage
靶点

GPR
受体

GRP35
研究领域

——
适应症

——

化学信息

CAS Number

264233-05-8
分子量

395.43
分子式

C17H19F2N5O2S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 125 mg/mL (316.11 mM)
SMILES

O=C(C1=C(C=NNC(NC(C)(C)C)=S)N(C2=CC=C(F)C=C2F)N=C1)OC
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Jenkins L , Harries N , Lappin J E , et al. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action[J]. Journal of Pharmacology & Experimental Therapeutics, 2012, 343(3):683-695.

计算器

浓度计算器

摩尔计算器

分子量计算器

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