Apostatin-1 ( Apt-1 )

产品货号. M24150 CAS No. 2559703-06-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Apostatin-1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Apostatin-1 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD N 端 TRAF2 结合域上的口袋结合。
产品描述

Apostatin-1 is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.
体外实验

Western Blot Analysis Cell Line:SH-SY5Y, HeLa, HT-29, and Jurkat cells Concentration:10 μM Incubation Time:6 h Result:Effectively induced autophagy by LC3 II induction and p62 reduction.
体内实验

Animal Model:Wild-type mice (n = 10, male, 8 weeks of age, systemic inflammation mouse model)Dosage:20 mg/kgAdministration:IP, onceResult:Reduced expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns, including interferon γ (IFNγ), lipopolysaccharide (LPS), Pam3CSK4 (a synthetic bacterial lipopeptide), and muramyl dipeptide (MDP). Showed increased survival following intravenous delivery of TNF, a mouse model of systemic inflammation.
同义词

Apt-1
通路

Others
靶点

Other Targets
受体

TRADD
研究领域

——
适应症

——

CAS Number

2559703-06-7
分子量

345.5
分子式

C19H27N3OS
纯度

>98% (HPLC)
溶解度

DMSO:65mg/ml(188.13mM; need ultrasonic); Ethanol:9mg/ml(26.06mM; need ultrasonic)
SMILES

O=C(NC1CCCCCC1)C(C2=CC=CC=C2)SC3=NCCN3C
化学全称

——

1.Xu D , Zhao H , Jin M , et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis[J]. Nature, 2020, 587(7832):1-6.

计算器

产品手册

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