021-51111890
购物车（）
sales@molnova.cn
TRPV4 agonist-1 free base
CAS No. 2314467-59-7
TRPV4 agonist-1 free base ( OUN67600 )
产品货号. M24056 CAS No. 2314467-59-7
TRPV4 agonist-1 free base 是一种瞬时受体电位香草酸亚型 4 (TRPV4) 激动剂，在 hTRPV4 Ca2+ 实验中 EC50 为 60 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥566 | 有现货 |
|
| 10MG | ￥895 | 有现货 |
|
| 25MG | ￥1758 | 有现货 |
|
| 50MG | ￥2771 | 有现货 |
|
| 100MG | ￥3717 | 有现货 |
|
| 200MG | ￥5022 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥752 | 有现货 |
|
生物学信息
-
产品名称TRPV4 agonist-1 free base
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述TRPV4 agonist-1 free base 是一种瞬时受体电位香草酸亚型 4 (TRPV4) 激动剂，在 hTRPV4 Ca2+ 实验中 EC50 为 60 nM。
-
产品描述TRPV4 agonist-1 free base?is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).
-
体外实验TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels.
-
体内实验——
-
同义词OUN67600
-
通路Membrane Transporter/Ion Channel
-
靶点TRP/TRPV Channel
-
受体TRPV4
-
研究领域——
-
适应症——
化学信息
-
CAS Number2314467-59-7
-
分子量448.46
-
分子式C25H22F2N4O2
-
纯度>98% (HPLC)
-
溶解度DMSO:83.33 mg/mL?(185.81 mM;?Need ultrasonic)
-
SMILESCN1CCN(CC1)C2=NC3=C(C=CC=C3F)C(=O)N2C4=CC=C(C=C4)OC5=CC=C(C=C5)F
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Jan 28.
