SU0268 ( —— )

产品货号. M23997 CAS No. 2210228-45-6

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

SU0268
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SU0268 是一种有效且特异性的 8-氧鸟嘌呤 DNA 糖基化酶 1 (OGG1) 抑制剂。 SU0268 调节铜绿假单胞菌感染期间的炎症反应。
产品描述

SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection.
体外实验

Cell Viability Assay Cell Line:A549 shGFP and shMTH1 (2000 cells per well).Concentration:0.1 μM, 0.5 μM, 1 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM.Incubation Time:24 or 48 h.Result:The shGFP cells were more susceptible to OGG1 inhibition via increasing SU0268 doses than the shMTH1 cells, especially at the 48 time-point.
体内实验

Animal Model:Anesthetized C57BL/6N mice.Dosage:10 mg/kg.Administration:Intranasally treated.Result:Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection.
同义词

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通路

Others
靶点

Other Targets
受体

8-oxoguanine DNA glycosylase 1 (OGG1)
研究领域

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适应症

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1.Ling Zhang, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021 Apr;40:101848.

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