BP 897

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2-Nathienecarboxamide, N-[4-[4-(2-甲氧基苯基)-1-哌嗪基]丁基]-是一种有效的选择性多巴胺 D3 受体激动剂，也是一种弱多巴胺 D2 受体拮抗剂。

2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]- is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3?μM, respectively).

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Animal Model:Male Listar hooded rats Dosage:0.05, 0.5, 1 mg/kg Administration:i.p.; 30 min before the session Result:Reduced cocaine-seeking behaviour before the first infusion of cocaine, in a dose-dependent manner, at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression.

2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-

GPCR/G Protein

Dopamine Receptor

D1|D2|D3|D4

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192384-87-5

417.55

C26H31N3O2

>98% (HPLC)

DMSO:10 mM

O=C(C1=CC=C2C=CC=CC2=C1)NCCCCN3CCN(C4=CC=CC=C4OC)CC3

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(-20℃)

With Ice Pack

≥ 2 years