Conoidin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Conoidin A 是弓形虫酶过氧化还原蛋白 II (TgPrxII) 的细胞渗透性抑制剂，具有杀线虫特性。

Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.

Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and signal transduction. And the changes in PrxII expression are associated with a variety of human diseases, including cancer.Conoidin A binds to the peroxidatic cysteine of TgPrxII, inhibiting its enzymatic activity?in vitro. Conoidin A also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in?Ancylostoma ceylanicum?and human PrxII and PrxIV with similar efficiency. But it is ineffective to mitochondrial hPrxIII.Conoidin A (5 μM) can inhibit the glucose oxidase-mediated hyperoxidation of mammalian peroxiredoxin I and II.

Conoidin A (intraperitoneal injection; 5?mg/kg; for three successive days before MI/R injury) blocks the effect of Luteolin (HY-N0162) on the ST‐segment elevation.?Furthermore, an increase in the infarct size presented of the MI/R group can be reduced by Luteolin. But pre‐treatment with conoidin A abolishs the effect of Luteolin. Pre‐treatment with conoidin A also prevents Luteolin-reduced activities of CK‐MB, AST and LDH in vivo. Animal Model:Rat myocardial I/R model Dosage:5?mg/kg Administration:Intraperitoneal injection; 5?mg/kg; for three successive days before MI/R injury Result:Significantly reversed the antioxidative effect of Luteolin.

——

Microbiology/Virology

Parasite

Parasite

——

——

18080-67-6

347.99

C10H8Br2N2O2

>98% (HPLC)

DMSO:14.29 mg/mL?(41.06 mM;?Need ultrasonic)

[O-][N+]1=C(CBr)C(CBr)=[N+]([O-])C2=CC=CC=C21

——

(-20℃)

With Ice Pack

≥ 2 years