LNP023 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LNP023 盐酸盐是一种口服生物利用度高、高效、高选择性的 B 因子抑制剂，IC50 为 10 nM。

LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.

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Animal Model:C57BL/6 mice with KRN-induced arthritis Dosage:20, 60, and 180 mg/kg Administration:Orally gavaged; twice a day (b.i.d.) for 14 days Result:Blocked KRN-induced arthritis.

Iptacopan HCl

Others

Other Targets

factor B

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1646321-63-2

458.98

C25H31ClN2O4

>98% (HPLC)

DMSO:250 mg/mL (544.69 mM; Need ultrasonic);H2O:50 mg/mL (108.94 mM; ultrasonic and warming)

O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years