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Heptamidine dimethanesulfonate
CAS No. 161374-55-6
Heptamidine dimethanesulfonate ( SBi4211 dimethanesulfonate )
产品货号. M23716 CAS No. 161374-55-6
Heptamidine dimethylsulfonate 是钙结合蛋白 S100B 的喷他脒相关抑制剂（Kd：6.9 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1378 | 有现货 |
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| 10MG | ￥2204 | 有现货 |
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| 25MG | ￥3701 | 有现货 |
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| 50MG | ￥5273 | 有现货 |
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| 100MG | ￥6912 | 有现货 |
|
| 200MG | ￥8883 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1691 | 有现货 |
|
生物学信息
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产品名称Heptamidine dimethanesulfonate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Heptamidine dimethylsulfonate 是钙结合蛋白 S100B 的喷他脒相关抑制剂（Kd：6.9 μM）。
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产品描述Heptamidine dimethanesulfonate is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM), selectively kills melanoma cells with S100B over those without S100B.?Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM).
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体外实验Heptamidine is a Pentamidine-S100B complex, two molecules of pentamidine bind per monomer of S100B, which performs to be an inhibitor for S100B.Heptamidine (20 μM) does not decrease CUG levels?significantly when compares to Propamidine and Pentamidine, and exhibits cytotoxic at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats.Heptamidine rescues mis-splicing of minigene reporters in a HeLa cell DM1 model with an EC50 value of 15 μM.
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体内实验Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion in?HSALR?mice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg. Animal Model:Homozygous?HSALR?transgenic mice in line 20b (FVB inbred background)?with a Myotonic dystrophy (DM) mouse model Dosage:20 or 30 mg/kg Administration:Intraperitoneal injection; 7 days; once daily Result:Reversed splicing defects and rescues myotonia in a DM mouse model.
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同义词SBi4211 dimethanesulfonate
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通路Others
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靶点Other Targets
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受体calcium-binding protein S100B
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研究领域——
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适应症——
化学信息
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CAS Number161374-55-6
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分子量560.68
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分子式C23H36N4O8S2
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纯度>98% (HPLC)
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溶解度DMSO:62.5 mg/mL (111.47 mM; Need ultrasonic)
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SMILESN=C(C1=CC=C(OCCCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N.CS(=O)(O)=O.CS(=O)(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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(-)-Syringaresinol
(-)-丁香脂素源自蒙大拿番荔枝的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖，并具有抗癌活性。
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IKKγ NBD Inhibitory ...
A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for the activation of the IKK complex and the subsequent activation of NF-kB.
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Corticotropin-releas...
Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions by reducing hyperpolarizations. Acts as a functional antagonist of inflammatory mediators.
