Zinc Protoporphyrin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Zinc Protoporphyrin 是一种口服活性的血红素加氧酶-1 (HO-1) 竞争性抑制剂，可显着减弱间苯三酚 (PG) 对 H2O2 的保护作用，并具有抗癌活性。

Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-cancer activity.

Apoptosis Analysis Cell Line:C-26 cells Concentration:5 μM Incubation Time:72 hoursResult:The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h.Cell Cytotoxicity Assay Cell Line:C-26 and MDA-MB231 cells Concentration:1.25, 2.5, 5, 10, 20, 40 μM Incubation Time:48 or 72 hours Result:Exerted cystostatic/cytotoxic effects against tumor cells.Cell Cycle Analysis Cell Line:C-26 cells Concentration:2.5, 5 μM Incubation Time:48 or 72 hours Result:Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle. Western Blot Analysis Cell Line:C-26 cells Concentration:1.25, 2.5, 5, 10, 20, 40 μM Incubation Time:48 hoursResult:Leaded to accumulation of cleaved (active) caspase-3.

Animal Model:BALB/c mice inoculated with C-26 cells Dosage:12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.Administration:IP or PO; from day 7 to 19 Result:Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.

Zn(II)-protoporphyrin IX | ZnPP | Zinc Protoporphyrin-9

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite|Reactive Oxygen Species

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15442-64-5

626.02

C34H32N4O4Zn

>98% (HPLC)

DMSO:50 mg/mL (79.87 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)

OC(CCC1=C(C=C2[N]3=C4C(C)=C2CCC(O)=O)[N-]([Zn+2]35[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O

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(-20℃)

With Ice Pack

≥ 2 years