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FIDAS-3
CAS No. 1266684-01-8
FIDAS-3 ( —— )
产品货号. M23438 CAS No. 1266684-01-8
FIDAS-3 有效地与 S-腺苷甲硫氨酸 (SAM) 竞争 MAT2A 结合。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥340 | 有现货 |
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| 10MG | ￥509 | 有现货 |
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| 25MG | ￥958 | 有现货 |
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| 50MG | ￥1395 | 有现货 |
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| 100MG | ￥1917 | 有现货 |
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| 200MG | ￥2619 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥324 | 有现货 |
|
生物学信息
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产品名称FIDAS-3
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述FIDAS-3 有效地与 S-腺苷甲硫氨酸 (SAM) 竞争 MAT2A 结合。
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产品描述FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding.?FIDAS-3 has anticancer activities.?FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A).
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体外实验FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosyl homocysteine (SAH) in LS174T cells.Cell Viability Assay Cell Line:LS174T colorectal cancer (CRC) cells Concentration:3 μM Incubation Time:7 days Result:Significantly inhibited the proliferation of LS174T cells.
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体内实验FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors. Animal Model:C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells Dosage:20 mg/kg Administration:Intraperitoneal injection; daily; for one months Result:Significantly inhibited the growth of xenograft tumors.
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同义词——
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通路Wnt/Notch/Hedgehog
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靶点Wnt/beta/catenin
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受体MAT2A|MATA2|Wnt
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研究领域——
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适应症——
化学信息
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CAS Number1266684-01-8
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分子量259.29
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分子式C16H15F2N
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纯度>98% (HPLC)
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溶解度DMSO:90mg/ml(347.10mM; Need ultrasonic)
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SMILESCN(C)C1=CC=C(/C=C/C2=C(F)C=CC=C2F)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803.
