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RO2959 Hydrochloride
CAS No. 1219927-22-6
RO2959 Hydrochloride ( RO2959 HCl )
产品货号. M23387 CAS No. 1219927-22-6
RO2959 盐酸盐是一种有效的选择性 CRAC 通道抑制剂 (IC50: 402 nM)。它也是人 IL-2 的有效抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1625 | 有现货 |
|
| 10MG | ￥2404 | 有现货 |
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| 25MG | ￥3674 | 有现货 |
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| 50MG | ￥4957 | 有现货 |
|
| 100MG | ￥6426 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1796 | 有现货 |
|
生物学信息
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产品名称RO2959 Hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述RO2959 盐酸盐是一种有效的选择性 CRAC 通道抑制剂 (IC50: 402 nM)。它也是人 IL-2 的有效抑制剂。
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产品描述RO2959 hydrochloride is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
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体外实验RO2959 inhibits Orai1 and Orai3 with IC50 values of 25 nM and 530 nM, respectively. RO2959 blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC50 value of 265 nM.RO2959 is a potent SOCE inhibitor that blocks an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either T cell receptor (TCR) stimulation or thapsigargin treatment. RO2959 completely inhibits cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction).
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体内实验——
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同义词RO2959 HCl
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通路GPCR/G Protein
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靶点Calcium Channel
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受体CRAC channel|IL-2
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研究领域——
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适应症——
化学信息
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CAS Number1219927-22-6
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分子量463.93
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分子式C21H20ClF2N5OS
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESCC1=C(CN(CC1)C2=NC=C(S2)C)C3=CN=C(C=N3)NC(=O)C4=C(C=CC=C4F)F.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Chen G, Panicker S, Lau KY, Apparsundaram S, Patel VA, Chen SL, Soto R, Jung JK, Ravindran P, Okuhara D, Bohnert G, Che Q, Rao PE, Allard JD, Badi L, Bitter HM, Nunn PA, Narula SK, DeMartino JA. Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions. Mol Immunol. 2013 Jul;54(3-4):355-67.
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