Sarecycline free base

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sarecycline 游离碱是一种四环素衍生的窄谱抗生素。

Sarecycline free base is a tetracycline-derived, narrow-spectrum antibiotic.

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Animal Model:Carrageenan-induced footpad edema male Sprague Dawley rats modelDosage:1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg Administration:Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.Result:Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.Animal Model:Carrageenan-induced footpad edema male Sprague Dawley rats model Dosage:0.33, 1, 3, or 9?mg/kg Administration:Intravenously Result:Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.

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Others

Other Targets

Others

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1035654-66-0

487.5

C24H29N3O8

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (205.13 mM)

CN(C)[C@@H]([C@H](C[C@H](Cc1c(CNCOC)ccc(O)c1C1=O)C1=C1O)[C@]11O)C(O)=C(C(N)=O)C1=O

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(-20℃)

With Ice Pack

≥ 2 years