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DUPA(OtBu)-OH
CAS No. 1026987-94-9
DUPA(OtBu)-OH ( —— )
产品货号. M23230 CAS No. 1026987-94-9
DUPA(OtBu)-OH 是 DUPA 前体。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥463 | 有现货 |
|
| 10MG | ￥744 | 有现货 |
|
| 25MG | ￥1228 | 有现货 |
|
| 50MG | ￥1702 | 有现货 |
|
| 100MG | ￥2349 | 有现货 |
|
| 200MG | ￥3231 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥491 | 有现货 |
|
生物学信息
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产品名称DUPA(OtBu)-OH
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DUPA(OtBu)-OH 是 DUPA 前体。
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产品描述DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
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体外实验DUPA(OtBu)-OH (DUPA precursor 17) is a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) reagent. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis. Besides, DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells.
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体内实验DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number1026987-94-9
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分子量488.57
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分子式C23H40N2O9
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL (255.85 mM; Need ultrasonic)
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SMILESCC(C)(C)OC(=O)CC[C@@H](C(=O)OC(C)(C)C)NC(=O)N[C@@H](CCC(=O)O)C(=O)OC(C)(C)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Roy J, et al. DUPA conjugation of a cytotoxic indenoisoquinoline topoisomerase I inhibitor for selectiveprostate cancer cell targeting. J Med Chem. 2015 Apr 9;58(7):3094-103.
产品手册
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