Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GAST 基因编码人类蛋白质 [Leu15]-胃泌素 I。在人类染色体中，基因 GAST 位于 17q21.2。胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体，即前胃泌素。

GAST gene encodes for the protein [Leu15]-Gastrin I in human.?In human chromosome, the gene GAST is localized on 17q21.2.?G cells in the stomach antrum produces the precursor of [Leu15]-Gastrin I, progastrin.Progastrin undergoes cleavage and processing to yield gastrin, which is trophic for the entire gastrointestinal epithelium.?Gastrin is essential for the growth of the digestive system and stimulates the production of gastric acid by parietal cells.?Gastrin exerts its function through G-protein-coupled receptor called the cholecystokinin (CCK) or CCK-B receptor (CCK-BR).?Gastrin release is stimulated by food, especially protein diet and is inhibited by very low pH. Atrophic gastritis, a Helicobacter pylori infection and long-term administration of proton pump inhibitors infection may cause overexpression of gastrin.?Gastric adenocarcinoma show high levels of gastrin.

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[Leu15]-Gastrin I human

Others

Other Targets

Others

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39024-57-2

2080.2

C98H126N20O31

>98% (HPLC)

In Vitro:?H2O : 10.53 mg/mL (5.06 mMu)

O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CC4=CC=C(O)C=C4)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC5=CNC6=C5C=CC=C6)NC([C@H]7N(C(CNC([C@H](CC8)NC8=O)=O)=O)CCC7)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

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(-20℃)

With Ice Pack

≥ 2 years