Kisspeptin-10, human (TFA)(374675-21-5,FREE)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Kisspeptin-10，人 TFA 是一种有效的血管收缩剂和血管生成抑制剂。 Kisspeptin-10，人 TFA 通过其受体 GPR54 充当肿瘤转移抑制剂。 Kisspeptin-10-GPR54系统在胚胎肾脏发育中发挥着重要作用。

Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis?inhibitor.?Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54.?Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development.?Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expressionKP-10-treatment significantly increased the expression of osteogenic genes, including mRNA and protein levels of BMP2, in C3H10T1/2 cells.?Moreover, KP-10 induced BMP2-luc activity and increased phosphorylation of Smad1/5/9.?In addition, NFATc4 specifically mediated KP-10-induced BMP2 gene expression.?However, KP-10 treatment did not induce expression of the BMP2 and Runx2 genes in GPR54-/- cells.?To examine whether KP-10 induced secretion of BMP2 to the culture medium, we used the conditioned-medium (C.M) of KP-10 treated medium on C3H10T1/2 cells.?Dlx5 and Runx2 expressions were higher in GPR54-/- cells treated with C.M than in those treated with KP-10.?

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Cell Cycle/DNA Damage

GPR

GPR54

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1416.46

C63H83N17O14.C2HF3O2

>98% (HPLC)

H2O:4 mg/mL (2.82 mM; Need ultrasonic)

CC([H])(C[C@](N=C(C/N=C([C@](CC1=CC=CC=C1)(N=C([C@](CO)(N=C([C@](CC(O)=N)(N=C([C@](CC2=CNC3=CC=CC=C23)(N=C([C@](CC(O)=N)(N=C([C@]([H])(CC4=CC=C(C=C4)O)N)O)[H])O)[H])O)[H])O)[H])O)[H])\O)O)(C(O)=N[C@@](CCCNC(N)=N)(C(O)=N[C@@](CC5=CC=CC=C5)(C(O)=N)[H])[H])[H])C.O=C(O)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years