GSK2807 Trifluoroacetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GSK2807 Trifluacetate 是一种 SMYD3 的选择性 SAM 竞争性抑制剂（Ki：14 nM；IC50：130 nM）。GSK2807 是一种有效的选择性 SMYD3 SAM 竞争性抑制剂（Ki = 14 nM）。高分辨率晶体结构揭示了 GSK2807 桥接了 SAM 结合袋和 SMYD3 的底物赖氨酸隧道之间的间隙。

GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).GSK2807, a potent and selective, SAM-competitive inhibitor of SMYD3 (Ki = 14 nM).?A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively).

A high-resolution crystal structure reveals that GSK2807 bridges the gap between the SAM-binding pocket and the substrate lysine tunnel of SMYD3. GSK2807 is 24-fold selective for SMYD3 in comparison with the closely related enzyme SMYD2 (Ki=14±6 nM and 345±36 nM, respectively).

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Others

Other Targets

SMYD3

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2245255-66-5

566.53

C21H33F3N8O7

>98% (HPLC)

H2O:50 mg/mL (88.26 mM)

NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC[C@H](N)C(O)=O)CCCN(C)C)O3)C=N2)=NC=N1.OC(C(F)(F)F)=O

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(-20℃)

With Ice Pack

≥ 2 years