SBI-477 ( —— )

产品货号. M22929 CAS No. 781628-99-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SBI-477
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SBI-477 是一种化学探针，通过灭活转录因子 MondoA 来刺激胰岛素信号传导。 SBI-477 协同抑制三酰甘油 (TAG) 合成并增强人骨骼肌细胞的基础葡萄糖摄取。
产品描述

SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes.??SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4).?Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation.?
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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1.Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79.

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