24-Norursodeoxycholic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

24-去甲熊去氧胆酸是 UDCA 的侧链缩短的 C23 同系物。它具有有效的抗炎、抗胆汁淤积和抗纤维化特性。它是熊去氧胆酸衍生物。在治疗 Mdr2 (Abcb4) 敲除小鼠的硬化性胆管炎方面，其优于熊去氧胆酸，24-去甲熊去氧胆酸显着改善肝脏检查和肝脏组织学，并显着降低羟脯氨酸含量以及浸润中性粒细胞和增殖肝细胞和胆管细胞的数量。

24-norursodeoxycholic acid is a side chain-shortened C23 homolog of UDCA.It has shown potent anti-inflammatory, anti-cholestatic, and anti-fibrotic properties.It is a Ursodeoxycholic Acid derivative. It is superior to Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice24-norUrsodeoxycholic acid markedly improved liver tests and liver histology and significantly reduced hydroxyproline content and the number of infiltrating neutrophils and proliferating hepatocytes and cholangiocytes.?24-norUrsodeoxycholic acid underwent extensive phase I/II metabolism (hydroxylation, sulfation, and glucuronidation), thereby increasing the hydrophilicity of biliary bile acid secretion.?There was a coordinated induction of bile acid detoxifying enzymes (Cyp2b10, Cyp3a11, and Sult2a1) and efflux pumps (Mrp3 and Mrp4).?Ursodeoxycholic acid, in contrast, increased alanine transaminase and alkaline phosphatase levels, had no significant effects on hydroxyproline content, and induced biliary transporters and detoxification enzymes to a much smaller extent than 24-norUrsodeoxycholic acid.

24-norursodeoxycholic acid (Norucholic acid) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels.

——

nor-UDCA

Others

Other Targets

Others

——

——

99697-24-2

378.55

C23H38O4

>98% (HPLC)

DMSO:100 mg/mL (264.17 mM; Need ultrasonic)

C[C@H](CC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

——

(-20℃)

With Ice Pack

≥ 2 years