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PTGR2-IN-22
CAS No. 349093-44-3
PTGR2-IN-22 ( —— )
产品货号. M22891 CAS No. 349093-44-3
PTGR2-IN-22 是 PTGR2r 的有效抑制剂 (IC50 : 0.7 μM)。它增加 PTGR2 转染的 HEK293T 细胞中 15-keto-PGE2 依赖性 PPARγ 转录活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥506 | 有现货 |
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| 10MG | ￥785 | 有现货 |
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| 25MG | ￥1386 | 有现货 |
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| 50MG | ￥1934 | 有现货 |
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| 100MG | ￥2583 | 有现货 |
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| 200MG | ￥3501 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥554 | 有现货 |
|
生物学信息
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产品名称PTGR2-IN-22
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PTGR2-IN-22 是 PTGR2r 的有效抑制剂 (IC50 : 0.7 μM)。它增加 PTGR2 转染的 HEK293T 细胞中 15-keto-PGE2 依赖性 PPARγ 转录活性。
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产品描述PTGR2-IN-22 is a potent inhibito of PTGR2r(IC50 : 0.7 μM). It increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells.
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体外实验A screen of structural analogs of 20 identified PTGR2-IN-1, which shows substantially increased potency (>20-fold) in assays measuring either competition of 8-labeling or 15-keto-PGE2 reductase activity (IC50 = 0.6 μM) of recombinant PTGR2, as well as an inactive control compound 23. PTGR2-IN-1 (Compound 22) blocks FFF 8 labeling of endogenous PTGR2 in HEK293T cells with good potency (complete inhibition at 5 μM and ~80% inhibition at 500 nM) and excellent selectivity.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体PTGR2
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研究领域——
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适应症——
化学信息
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CAS Number349093-44-3
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分子量310.39
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分子式C19H22N2O2
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (322.18 mM; Need ultrasonic)
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SMILESCOC1=CC=CC=C1N2CCN(C(CC3=CC=CC=C3)=O)CC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Parker CG, et al. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017;168(3):527-541.e29.
产品手册
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