HODHBt ( —— )

产品货号. M22874 CAS No. 28230-32-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HODHBt
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HODHBt 是一种 STAT5-SUMO 蛋白质-蛋白质相互作用抑制剂。
产品描述

HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.
体外实验

HODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells.HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells).HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10).HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro.
体内实验

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同义词

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通路

JAK/STAT Signaling
靶点

STAT
受体

STAT5
研究领域

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适应症

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