Skullcapflavone II

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Skullcapflavone II 是一种从黄芩中提取的黄酮类化合物，黄芩是一种广泛用于抗炎和抗癌治疗的草药。

Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy.?Skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.Skullcapflavone II regulates osteoclast differentiation, survival, and function.?Skullcapflavone II exerts potent antimicrobial activity against M. aurum and M. bovis BCG.

Skullcapflavone II inhibits osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. Skullcapflavone II decreases reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency.

Skullcapflavone II, a potential bradykinin antagonist, reduces the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways.

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Others

Other Targets

TGFβ|COX

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55084-08-7

374.35

C19H18O8

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (133.57 mM)

COC1=C2C(C(C=C(C3=C(C=CC=C3O)OC)O2)=O)=C(O)C(OC)=C1OC

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(-20℃)

With Ice Pack

≥ 2 years