Chebulinic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Chebulinic Acid 是结核分枝杆菌 DNA 旋转酶的有效抑制剂。它还可以抑制 SMAD-3 磷酸化和 H+ K+-ATPase 活性。Chebulinic Acid 明显抑制 HQ/Cu(II)- 和 H(2)O(2)/Cu(II) 介导的 pBR322 DNA 链断裂。当用 HQ/Cu(II) 处理 MRC-5 细胞时，Chebulinic 酸的存在抑制了 HQ/Cu(II) 介导的基因组 DNA 双链断裂。

Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.Chebulinic acid obviously inhibited HQ/Cu(II)- and H(2)O(2)/Cu(II)-mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu(II), the presence of Chebulinic acid inhibited HQ/Cu(II)-mediated double-strand breaks of genomic DNA [1].Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L.

In vitro: binding of Chebulinic acid causes displacement of catalytic Tyr129 away from its target DNA-phosphate molecule. Chebulinic acid reduce the expression and activity of MMP-2at an ED50 value of 100 μM. EMT (Epithelial to Mesenchymal Transition) is found to be induced in ARPE-19 cells, through SMAD-3 phosphorylation and it is inhibited by CA. chebulinic acid significantly inhibited H+ K+-ATPase activity in vitrowith IC50 of 65.01 μg/ml.

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GPCR/G Protein

Antibacterial

bacterial DNA gyrase| Smad3| H+/K+-ATPase

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18942-26-2

956.68

C41H28O27

>98% (HPLC)

DMSO:Soluble

OC(C[C@H](C(O[C@@]([C@H](O[C@H]1OC(C2=CC(O)=C(O)C(O)=C2)=O)COC(C3=CC(O)=C(O)C(O)=C3)=O)([H])[C@@](OC(C4=CC(O)=C(O)C(O)=C4)=O)([H])[C@@]1([H])OC5=O)=O)[C@@]([C@H]6O)([H])C(C5=CC(O)=C7O)=C7OC6=O)=O

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(-20℃)

With Ice Pack

≥ 2 years