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MitoBloCK-10
CAS No. 394694-98-5
MitoBloCK-10 ( 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m )
产品货号. M22749 CAS No. 394694-98-5
MitoBloCK-10 抑制 Tim44 与前体和 Hsp70 的结合。MitoBloCK-10 是第一个减弱蛋白质相关运动 (PAM) 复合物活性的小分子调节剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1454 | 有现货 |
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| 10MG | ￥2204 | 有现货 |
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| 25MG | ￥3655 | 有现货 |
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| 50MG | ￥5236 | 有现货 |
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| 100MG | ￥7047 | 有现货 |
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| 200MG | ￥9450 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1340 | 有现货 |
|
生物学信息
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产品名称MitoBloCK-10
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MitoBloCK-10 抑制 Tim44 与前体和 Hsp70 的结合。MitoBloCK-10 是第一个减弱蛋白质相关运动 (PAM) 复合物活性的小分子调节剂。
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产品描述MitoBloCK-10 inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity.
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体外实验Cell Viability Assay Cell Line:A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains.Concentration:100 μM.Incubation Time:30 min.Result:WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil.Cell Viability Assay Cell Line:HeLa cells.Concentration:0-100 μM.Incubation Time:24 h.Result:Inhibited HeLa cells vibility, with an IC50 of 17.2 μM.
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体内实验——
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同义词3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number394694-98-5
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分子量293.28
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分子式C12H8FN3O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (426.23 mM)
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SMILES[O-][N+](=O)c1ccc(\C=N\NC(=O)c2cccc(F)c2)s1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Non Miyata, et al. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31;292(13):5429-5442.
