MID-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MID-1 是 MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) 相互作用的抑制剂。它破坏 MG53 与 IRS-1 的分子关联，并消除 MG53 诱导的 IRS-1 泛素化和骨骼肌降解，导致 IRS-1 表达水平升高、胰岛素信号传导和葡萄糖摄取增加。

MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.?It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake.

MID-1 (5 μM; 24 h) increases the IRS-1 expression level in skeletal muscle by disrupting the MG53-IRS-1 interaction.MID-1 (10 μM; 12 h) reduces the luciferase activity in HEK 293 cell line expressing NLUC-IRS-1 and CLUC-C14A.MID-1 (1-20 μM; 12 h) disrupts the MG53-IRS-1 interaction but not MG53-FAK interaction in HEK 293 cells.MID-1 (0.1-10 μM; 4-24 h) abolishes MG53-induced IRS-1 ubiquitination and degradation in HEK 293 cells.MID-1 (5-10 μM; 24 h) increases insulin signaling and insulin-elicited glucose uptake in C2C12 myotubes.MID-1 (5-10 μM; 24 h) enhances skeletal myogenesis.Western Blot Analysis Cell Line:C2C12 myotubes Concentration:5 μM Incubation Time:24 h Result:Increased the IRS-1 protein level.

MID-1 does not have good pharmacokinetics in vivo.

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Others

Other Targets

MG53-IRS-1

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312608-54-1

293.3

C12H11N3O4S

>98% (HPLC)

DMSO:31.25 mg/mL?(106.55 mM;?Need ultrasonic)

CCOc1ccc(cc1)C(=O)Nc1ncc(s1)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years