TH1020

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TH1020 是一种新型 Toll 样受体 5 (TLR5)/鞭毛蛋白复合物抑制剂，具有良好的活性 (IC50 =0.85±0.12)μm）和特异性。

TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12?μm) and specificity.TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation.?Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5.?TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5.

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GPCR/G Protein

Antibacterial

TLR5|Bacterial

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1841460-82-9

453.54

C23H15N7S2

>98% (HPLC)

DMSO:2 mg/mL (4.41 mM; ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 80°C)

C(c1ccccc1)n1c(Sc2ncnc3c4cccnc4sc23)nnc1-c1ccncc1

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(-20℃)

With Ice Pack

≥ 2 years