Indolelactic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

吲哚乳酸是维氏固氮菌培养物中色氨酸的代谢产物。

Indolelactic acid is a metabolite of tryptophan in Azotobacter vinelandii cultures.

Indolelactic acid (1 mM, 5 days) upregulates CXCR3, granzyme B, and immunoregulatory galectin-1 in Th2 cells.Indolelactic acid (0.1-10mM, 1 h) significantly inhibits LPS-induced inflammation in RAW blue macrophages and Caco-2 cells.Indolelactic acid (0.1-10mM, 1 h) inhibits TNF-α induced inflammation in HT-29 cells.Indolelactic acid (10mM, 1 h) activates the AhR and downstream Nrf2 pathway in Caco-2 cells.Indolelactic acid (5 μM, 24 h) enhances the IFIT2 and RSAD2 mRNA expression in H4 cells stimulated by IL-1β. RT-PCR Cell Line:HT-29 cells Concentration:0.1, 1, 10?mMIncubation Time:1 h Result:Decreased IL-8 level induced by TNF-α, and increased β-defensin 2 and SERT level.

Indolelactic acid (gavage feeding, 10 μM, 5 μL, 5 days, C57BL/6 mice) benefits the immature intestine preferentially. Animal Model:C57BL/6 mice Dosage:10 μM, 5 μL Administration:Gavage feeding, 5 days Result:Upregulated the innate immune response genes in immature mouse intestine (C57-pup-ileum), with no effects on pup-colon or adult intestine.

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Proteasome/Ubiquitin

Endogenous Metabolite

Endogenous Metabolite

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1821-52-9

205.21

C11H11NO3

>98% (HPLC)

DMSO:82 mg/mL (399.59mM; Need ultrasonic)

O=C(O)C(O)Cc2cnc1ccccc12

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(-20℃)

With Ice Pack

≥ 2 years