4-hydroxyphenyl acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

4-乙酰氧基苯酚通过充当 NRF2 稳定剂来防止 RPE 氧化应激诱导的坏死4-AC 是一种天然抗氧化剂，具有很强的保护 RPE 细胞免受氧化应激诱导的坏死的能力。

4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer4-AC is a natural antioxidant, which demonstrates strong abilities to protect RPE cells from oxidative stress-induced necrosis. Mechanistically, 4-AC blocked the increase of cellular ROS induced by oxidative stress, and upregulated NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor. The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP. The tBHQ, an NRF2 stabilizer, consistently mimicked the protective effect of 4-AC against tBHP-induced RPE death.

4-Hydroxyphenyl acetate (5 μM; 24 h) protects retinal pigment epithelial (RPE) cells from oxidative stress-induced cell death.4-Hydroxyphenyl acetate (5 μM; 24 h; ARPE-19 cells) inhibits the increase of ROS in response to oxidative stress and up-regulated the expression of cytoprotective genes including NQO1 and HO-1 genes. Cell Viability Assay Cell Line:ARPE-19 cells Concentration:5 μM Incubation Time:24 hours Result:Protected up to 89%, 92%, and 90% of ARPE-19 cells exposed to 100, 200, and 300 μM tBHP, respectively.

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Nuclear Receptor/Transcription Factor

Keap1-Nrf2

NRF2

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3233-32-7

152.15

C8H8O3?

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (657.25 mM)

CC(=O)Oc1ccc(O)cc1

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(-20℃)

With Ice Pack

≥ 2 years