6-AZATHYMINE

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

6-azathymine 是 D-3-氨基异丁酸丙酮酸转氨酶的有效抑制剂。 6-氮尿嘧啶对于 β-丙氨酸是一种竞争性抑制剂，对于丙酮酸是一种非竞争性抑制剂，Ki 约为 8.9 mM。

6-azathymine is a potent inhibitors of D-3-aminoisobutyrate-pyruvate aminotransferase.?6-Azauracil acted as a competitive inhibitor with respect to beta-alanine, and was an uncompetitive inhibitor with respect to pyruvic acid with a Ki of approximately 8.9 mM.

6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine.

The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it. Following the administration of 6-Azathymine-5-14C to mice, radioactivity is found in all tissues investigated, not only in the form of free Azathymine, but also as metabolic derivatives.

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GPCR/G Protein

Antibacterial

Bacterial

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932-53-6

127.1

C4H5N3O2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (983.48 mM)

Cc1n[nH]c(=O)[nH]c1=O

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(-20℃)

With Ice Pack

≥ 2 years